OBJECTIVE： To provide reference for improving the pharmacy self-taught undergraduate course system in general universities in China. METHODS： According to comparative study and researching related literatures， the situation of pharmacy self-taught undergraduate course system in general universities in China was analyzed， and reform ideas and programs were presented. RESULTS & CONCLUSIONS： Based on “chemistry-biology-psychology-society-medicine-pharmacy” in the overall framework of pharmacy undergraduate self-examination course system， it was designed with target of cultivating applied talents； related contents in public basic courses， humanities basic course and professional ethics course should throughout the whole teaching process； professional main course should be pharmaceutical knowledge-based， supplemented by medical related courses； the school should set vocational elective course to reform based on combining with the own teaching research direction， characteristics and career orientation of different self-taught students. The reform can develop applied talents with ability and political integrity， which meets the needs of social development.