OBJECTIVE： To compare the efficacy and safety of conventional triple/quadruple therapy for patients with Hp positive in the digestive tract ulcer. METHODS： 96 patients with Hp infection in the digestive tract ulcer were randomly divided into control group （48 cases） and observation group （48 cases）. Observation group received Rabeprazole enteric-coated tablet 10 mg/times， twice/d + Amoxicillin capsule 1.0 g/times， twice/d+Clarithromycin capsule 0.5 g/times， twice/d +Bismuth potassium citrate capsule 220 mg/d， twice/d. Control group received Rabeprazole enteric-coated tablet 10 mg/times， twice/d + Amoxicillin capsule 1.0 g/times， twice/d + Clarithromycin capsule 0.5 g/times， twice/d. They treated for 14 d. Hp eradication， improvement of clinical symptoms， ulcer healing and the incidence of adverse reactions in 2 groups were compared. RESULTS： The Hp eradication rate， total effective rate of the improvement of clinical symptoms and total effective rate of ulcer healing in observation group were significantly higher than control group， with statistical significance （P＜0.05）. And there was no significant difference in the total incidence of adverse reactions in 2 groups （P＞0.05）. CONCLUSIONS： The efficacy of conventional quadruple therapy is superior to conventional triple therapy in the treatment of Hp infection in the digestive tract ulcer， which can improve Hp eradication rate， clinical symptoms and ulcer healing， with similar safety.