OBJECTIVE： To investigate the constitution of drug use in large-scale ophthalmic center， and to guide and strengthen pharmaceutical administration of ophthalmic medication. METHODS： The data of consumption sum and quantity of ophthalmic drugs was obtained from a large-scale ophthalmic center during 2013-2015， which was processed， analyzed and evaluated with a method of consumption sum， DDD and DDDs analysis. RESULTS： 5 categories were involved， including 26 subcategories， 135 speification. The consumption sum of other ophthalmic drugs accounted for 56.70％ of total consumption sum， and the proportion of consumption quantity was 52.42％.  Artifical tears， ophthalmic lubricant and astringent took up the first place of consunption sum and quatitity. Antibiotics were the most commonly used ophthalmic drugs for infection. The ophthalmic anti-inflammatory drugs were mainly other kinds of anti-inflammatory drugs， supplemented by glucocorticoid. Serial number ratio （B/A） of prostaglandin analogue and carbonic anhydrase inhibitor， etc among drugs for glaucoma was lower than 0.5. The domestic ophthalmic drug accounted for 57.77％ of total consumption sum and 69.42％ of total consumption quantity. The ophthalmic essential medicine only shared 7.92％ of total consumption sum. The proportion of antibiotics for local external use was higher than 30.00％ in outpatient department and higher than 94.00％ in the inpatient department. The incidence of ADR induced by high-dose corticosteroid therapy was 17.19％.  CONCLUSIONS： Assistant medication ought to become a key point of ophthalmic pharmaceutical administration. It is necessary to strengthen specialty medication management of ophthalmic antibiotics， prostaglandin analogue and glucocorticoid so as to promote rational use of them. Domestic drugs share the main ophthalmic medication market， but domestic drugs R&D is to be strengthened. Ophthalmic essential medicine is in short supply， and it is urgent to enrich essential medicine list.