OBJECTIVE： To strengthen the supervision of clinical antibiotics use through establishing electronic consultation system. METHODS： Based on hospital information system （HIS） and antibiotic management system， consultation system for antibiotics of special use （ASU） was established， and the effects of the system after used （Jan. 2014） were also evaluated. RESULTS： Real-time consultation of ASU medical orders and related consultation results inquiry and statistics could be achieved through designing ASU consultation application form， establishing consultation experts and confirming their working content， adding statistics function， etc. The consultation have been finished 8 275 times from 2014 to 2015. The inspection rate for pathogenic microbes in ASU patients rose from 78.68％ in 2013 to 83.90％ in 2015. CONCLUSIONS： The establishment and application of ASU consultation system can improve consultation efficiency and quality， so as to promote rational use of antibiotics in the clinic.