OBJECTIVE： To investigate the anti-inflammatory and analgesic effects of mongolian medicine Cymbaria dahurica extract. METHODS： 96 KM mice （or SD rats） were randomly divided into model group （water）， positive control group （aspirin， 0.5 g/kg）， C. dahurica ethanol extract （70％ ethanol） low-dose， medium-dose and high-dose groups （0.325， 0.650， 1.300 g/kg， calculated by crude drug） and C. dahurica aqueous extract of the residue of alcohol extraction low-dose， medium-dose and high-dose groups （0.325， 0.650， 1.300 g/kg， calculated by crude drug）. They were given relevant medicine intragastrically， once a day， for consecutive 7 d. The xylene-induced ear edema method was used to determine the degree of ear edema， and egg white-induced paw edema method was used to determine paw edema after inducing inflammation 1， 2， 4， 6 h； anti-inflammatory activity of C. dahurica extract was investigated. 96 KM mice were grouped and given medicine with same method； the number of writhing within 20 min was determined by acetic acid writhing method. Another 64 KM mice were grouped with same method， with 8 mice in each group； except positive control group was given tramadol hydrochloride （0.5 g/kg） intragastrically， other groups were given relevant medicine with same method. Pain thresholds of mice were determined by hot-plate test before and after medication 30， 45， 60， 90 min， and analgesic effects of C. dahurica extract were investigated. RESULTS： Compared with model group， C. dahurica extract could obviously restrain the ear edema of mice and paw edema of rats 6 h after egg white-induced inflammation. Except paw edema of rats in C. dahurica aqueous extract of the residue of alcohol extraction high-dose group was decreased slightly， there was statistical significance among other groups （P＜0.05 or P＜0.01）. C. dahurica extract decreased the number of writhing in mice within 20 min， and extended pain thresholds of mice 30， 60， 90 min after medication （P＜0.05）. CONCLUSIONS： Both   C. dahurica ethanol extract and aqueous extract of the residue of alcohol extraction posses certain anti-inflammatory and analgesic effects.