OBJECTIVE： To establish the evaluation standards for clinical use of human serum albumin （HSA）， in order to provide basis for special comment and reasonable use of HSA in our hospital. METHODS： By using hospital information system and rational drug use monitoring system， clinical pharmacists analyze the use of HSA and main indications in 2014. In evidence-based medicine study， using “baidanbai” “albumins” “albuminoid” and main indications （such as “hepatorenal syndrome”， etc.） as keywords， retrieved from Cochrane Library， PubMed， Embase and other database， related evidence-based medicine evidence were collected. According to evidence level and recommended level， preliminary evaluation standards were developed for clinical use of HSA in our hospital. After the standards was revised by the experts in relevant departments， the evaluation standards for clinical use of HSA in our hospital was finally formed. RESULTS & CONCLUSIONS： HSA was used in 35 clinical departments of our hospital in 2014. 10 kinds of major indications included hypoalbuminemia，  cirrhosis ascites， bacterial peritonitis， hepatorenal syndrome and surgical operation， etc. A total of 131 literatures were retrieved. According to evaluation standard for clinical use of HSA in our hospital， 10 kinds of indications involved recommended indications （hepatorenal syndrome， cirrhosis ascites， spontaneous bacterial peritonitis， cardiac surgery）， appropriate use of indications （neonatal jaundice， septic shock， hemorrhagic shock， burnt， nephrotic syndrome， gastrointestinal surgical procedures） and non-indications （hypoalbuminemia）， etc. At the same time， the indications， administration program， the level of evidence and recommended were listed for each indication. But the standard should be improved continuously so as to further promote rational use of HSA.