OBJECTIVE： To evaluate the effectiveness， safety and economics of antibiotics for inpatients with acute exacerbation of chronic obstructive pulmonary diseases （AECOPD）， in order to promote rational use of antibiotics. METHODS： In retrospective study， AECOPD inpatients were selected as research objects during 2013-2015 to evaluate the use of antibiotics. RESULTS： Three thousand one hundred and eighty-six AECOPD patients were enrolled in the study， and utilization ratio of antibiotics was above 90％. DDDs of Cefordizime sodium  for injection ranked the first place in 3 years and was decreased in 2015， while those of β-lactam and carbapenems were increased. DDC of Meropenem for injection and Imipenem/cilastatin sodium for injection were the highest. Drug utilization index （DUI） of Cefodizime for injection was far more than 1.0， while DUI of Piperacillin sodium and sulbactam sodium for injection was much less than 1.0. Sort ratio （B/A） of Cefodizime sodium for injection ranged 1-2 in 3 years. B/A of Piperacillin sodium and sulbactam sodium for injection， Imipenem and cilastatin sodium for injection， Meropenem for injection were lower than 1.0. CONCLUSIONS： The indication of anti-infective treatment in AECOPD patients have been mastered strictly in our hospital； the utilization ratio of antibiotics is decreased year by year； the types of antibiotics are rational relatively， and the number of antibiotics which is rationally used is increased year by year. But the rationality of Cefodizime sodium for injection and Piperacillin sodium/sulbactam sodium for injection need to be improved.