OBJECTIVE： To investigate the protective effect of Miao medicine Liqi huoxue dropping pills on myocardial ischemia-reperfusion injury （MIRI） model rats. METHODS： 60 rats were randomized into sham operation group， model group， simvastatin group （positive control， 40 mg/kg） and Liqi huoxue dropping pills low-dose， medium-dose and high-dose groups （43.75， 87.50， 175.00 mg/kg）， with 10 rats in each group. Treatment groups were given relevant medicine intragastrically once a day for 10 days. Sham operation group and model group were given constant volume of normal saline intragastrically. 45 min after last administration， MIRI model was induced in those groups except for sham operation group. The situation of cardiac arrhythmia in rats was monitored after reperfusion. The myocardium tissue morphology was observed by hematoxylin-eosin（HE） staining； the activity of myocardial [creatine kinase （CK） and lactate dehydrogenase （LDH）] in serum were measured by enzyme dynamics method； the contents of tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） in serum were detected by enzyme linked immunosorbent assay （ELISA）. RESULTS： Compared with sham operation group， rats in model group suffered from more serious arrhythmia and myocardial tissue damaged， and the activities of CK and LDH and the contents of TNF-α and IL-6 were increased significantly （P＜0.01）. Compared with model group， arrhythmia degrees of rats were decreased in simvastatin group and Liqi huoxue dropping pills medium-dose and high-dose groups， and pathological changes of myocardial tissue was improved， while the activities of CK and LDH and the contents of TNF-α and IL-6 in serum were decreased significantly （P＜0.01）； those indexes of Liqi huoxue dropping pills high-dose group were close to those of simvastatin group （P＞0.05）.  CONCLUSIONS： Liqi huoxue dropping pills have the protective effect on MIRI model rats， and its mechanism may be related to decreasing myocardial enzyme leaking of cardiac muscle cell， decreasing the serum contents of TNF-α and IL-6 and inhibiting the inflammatory injury.