OBJECTIVE： To improve the electronic prescription prior-review mode and increase the rate of qualified prescriptions. METHODS： The electronic prescription prior-review mode of our hospital was established by setting up outpatient and emergency electronic prescription review team， review evidence and enforcement measures. Aimed at these problems as low review efficiency at initial stage， non-unified standards and untimely feedback， quality control circle and internet tools WeChat were used to improve the mode and evaluate its effects. RESULTS： The electronic prescription prior-review mode of our hospital was improved by optimizing system settings， unifying review standard， one-to-one feedback and communication with WeChat public platform， etc. Average time of prescription prior-review had reduced from 50 s to 30.58 s； the rate of qualified prescriptions had increased from 86.77％ to 95.30％； prescription review efficiency and the rate of qualified prescriptions had been improved significantly. CONCLUSIONS： The implementation and continuous improvement of electronic prescription prior-review mode can reduce the rate of unqualified prescriptions and promote rational drug use in outpatient and emergency department.