OBJECTIVE： To compare effects of Phellodendron chinense， stir-baked P. chinense with yellow rice wine and stir-baked P. chinense with salt solution on thyroid gland and adrenocortical function of kidney-Yin deficiency model rats with hyperthyroidism. METHODS： 88 rats were randomly divided into blank group， model group， yellow rice wine group， salt solution group， positive group （Liuwei dihuang pills， 0.2 g/kg， calculated by crude drug）， high-dose and low-dose groups of P. chinense， stir-baked P. chinense with yellow rice wine and stir-baked P. chinense with salt solution （9.519， 1.058 g/kg， calculated by crude drug）. Except for blank group， other groups were given levothyroxine sodium to induce kidney-Yin deficiency model； during modeling， treatment groups were given relevant medicine intragastrically， and other groups were given constant volume of solution intragastrically， once a day， for consecutive 3 weeks. After last administration， body weight， 24 h urine amount， viscera （thymus， spleen） indexes were determined； the serum levels of free triiodothyronine （FT3）， free thyroxine （FT4）， vasopressin （AVP）， cAMP and cGMP were determined as well as urine levels of 17-hydroxy steroid （17-OHCS）. cAMP/cGMP ratio was also calculated. RESULTS： Compared with blank group， body weight， 24 h urine amount and viscera （thymus， spleen） indexes were decreased significantly in model group； serum levels of FT3， FT4， AVP and cAMP， cAMP/cGMP ratio and urine level of 17-OHCS were increased significantly， while serum level of cGMP was decreased significantly， with statistical significance （P＜0.01）. Except for the body weight in stir-baked P. chinense with yellow rice wine group and the serum level of cGMP in high-dose and low-dose of stir-baked P. chinense with yellow rice wine group， above indexes of positive group， high-dose and low- dose groups of P. chinense， stir-baked P. chinense with yellow rice wine and stir-baked P. chinense with salt solution were all improved significantly （P＜0.05 or P＜0.01）. The improvement degree order was as follows as stir-baked P. chinense with salt solution＞P. chinense＞stir-baked P. chinense with yellow rice wine. Serum level of cAMP and cAMP/cGMP ratio in stir-baked P. chinense with salt solution high-dose group and serum levels of 17-OHCS in stir-baked P. chinense with salt solution high-dose and low-dose groups were significantly lower than in same dose group of P. chinense. CONCLUSIONS： P. chinense can improve thyroid gland and adrenocortical function of kidney-Yin deficiency model rats with hyperthyroidism ， which can be enhanced by stir-baked with salt solution but attenuated by stir-baked with yellow rice wine. It indicates that Yin-nourishing effect of P. Chinese have been enhanced after stir-baked with salt.