OBJECTIVE： To explore the application of propensity score matching in the rationality evaluation of outpatients glucocorticoid prescriptions. METHODS： 1 271 outpatient prescriptions including glucocorticoid drugs in 2015 were selecteds by equal probability cluster sampling from nerth district of our hospital. According to drug package inserts， Guiding Principles for Clinical Application of Glucocorticoid Drugs and clinical guidelines， the rationality of glucocorticoid used in prescriptions were judged irrational ones were included in irrational prescriptions （IP） group. Rational prescriptions （RP） group included the same number which were selected from rational prescriptions by propensity score matching （PSM） and were in line with irrational ones in respects of gender， age and medical insuranc （P＝1）.  The differences between 2 groups were compared in respects of disease system， dosage form， route of administration and drug dosage. RESULTS： There were 1 168 rational prescriptions （91.90％） and 103 irrational ones （8.10％） in 1 271 prescriptions. After PSM， 2 groups of ochincluded 103 prescriptions， there was no statistical difference between RP group and IP group in terms of dosage form （P＝0.962）， route of administration （P＝0.246） and DDDs （P＝0.307）. For disease system， disease diagnose of 56 prescriptions （54.4％） in IP groups went beyond guideline principle， while one prescription （1.0％） in RP group， with statistical significance （P＜0.001）. Among irrational prescription analysis， 99 prescriptions（96.1％） were irrational indication， and 4 prescriptions （3.9％） were irrational route of administration. CONCLUSIONS： PSM is helpful to find out the factors inducing irrational prescription， pharmacists should be careful and focus on rationality judgement when they find that disease system is berond guiding principle.