OBJECTIVE： To observe the clinical efficacy of Tuibai granules combined with narrow band UVB （NB-UVB） radiation in the treatment of vitiligo vulgaris and their effects on ICAM-1 and CXCL9 of peripheral blood. METHODS： 60 patients with vitiligo vulgaris were selected and treated with Tuibai granules dissloved in 200 ml water， orally， combined with NB-UVB local radiation for 3 months. Another 30 healthy volunteers were chosen as control group. Clinical efficacies of different stage， different skin lesion areas and different disease courses were observed as well as the serum levels of ICAM-1 and CXCL9 before and after treatment， which were compared with control group. RESULTS： Total effective rates of patients were 88.24％ in progressive stage， 87.10％ in those with skin lesion areas ＜5％ and 87.50％ in those with disease course＜1 year， which were significantly higher than 61.54％ in stable stage， 65.52％ in those with skin lesion area ≥5％ and  64.29％ in those with disease course ≥1 year， with statistical significance （P＜0.05）. Before treatment， the levels of ICAM-1 and CXCL9 in all kinds of patients were all higher than in healthy control group； those of progressive stage were higher than those of stable stage； those of skin lesion area ≥5％ was higher than those of skin lesion area＜5％； those of disease course＜1 year was higher than those of disease course ≥1 year， with statistical significance （P＜0.05）. After treatment， the levels of ICAM-1 and CXCL9 in all kinds of patients were significantly lower than before except for those in stable stage， with statistical significance （P＜0.05）. CONCLUSIONS： Tuibai granules combined with NB-UVB radiation shows good therapeutic efficacy in the treatment of vitiligo vulgaris， and can reduce the expression of ICAM-1 and CXCL9.