OBJECTIVE： To explore the clinical utilization of carbapenems in a hospital， analyze and evaluate its medication rationality. METHODS： All the 508 medical records of inpatients treated with carbapenems from Jul. 2012 to Jun. 2015 were retrospectively investigated， the utilization and pathogenic examination of carbapenems were evaluated； by setting the carbapenems evaluating standard， the medication rationality of carbapenems was evaluated and inappropriate cases were classified and analyzed statistically. RESULTS： The drug utilization indexed （DUI） of Imipenem and cilastatin sodium for injection and Meropenem for injection were 0.80 and 1.32， respectively； the total rate of microbial inspection was 95.9％； according to the drug sensitive test result， the rate of drug selection was 62.8％； there were 54 cases （10.6％） of irrational use records， in which， irrational dosage （42.6％） and improper drug selection （31.4％） were the major problems. CONCLUSIONS： There are some inappropriate medication problems in carbapenems utilization in the hospital. Developing the carbapenems utilization evaluation is helpful to discover typical medication problems， which can provide reference for intervention and continuous improvement of rational drug use.