OBJECTIVE： To investigate the effects of glutamine on neurological and gastrointestinal function of severe organophosphate poisoning patients. METHODS： 46 patients with severe organic phosphorus poisoning in our hospital were enrolled and randomly divided into control group and observation group， with 23 cases in each group. Control group was given antidote atropine， energy recovery agent pralidoxime chloride， blood perfusion and other symptomatic treatment. Observation group was additionally given Glutamine dipeptide injection 0.5 g/kg，ivgtt，qd， on the basis of control group. Both groups received the treatment for consecutive 3 d. The time of poisoning symptom disappearance， the time of blood cholinesterase recovery， hospitalization time， neurological and gastrointestinal function indexes were compared between 2 groups. RESULTS： The time of poisoning symptom disappearance， the time of blood cholinesterase recovery and hospitalization time of observation group were significantly shorter than those of control group， with statistical significance （P＜0.05）. After treatment， serum diamine oxidase and lactulose/mannitol of observation group were significantly lower than those of control group， while the serum content of citrulline was higher than in control group， with statistical significance （P＜0.05）. After treatment， MCV and SCV of observation group were significantly higher than those of control group， while F wave latency was significantly shorter than control group， with statistical significance （P＜0.05）. CONCLUSIONS： Glutamine dipeptide is helpful to promote remission， improve gastrointestinal and neurological function.