OBJECTIVE： To compare cost-effectiveness of Xiyanping injection and Ribavirin injection in the treatment of common type hand-foot-mouth disease （HFMD） in children， and to provide evidence for rational drug use in the clinic. METHODS： The literatures about Xiyanping injection in the treatment of common type HFMD in children using Ribavirin injection as control were retrieved from CNKI， VIP， Wanfang， PubMed， Cochrane library and other databases. The decision tree was established with TreeAge Pro 2011 software to conduct cost-effectiveness analysis. Tornado diagram was used to analyze sensitive factors；  single factor and double factors sensitivity analysis were also conducted. RESULTS & CONCLUSIONS： The total cost of Xiyanping injection and Ribavirin injection were 2 887.53 and 3 058.72 yuan， respectively. The total effective rates were 92.49％ and 78.12％. Xiyanping injection shows cost-effectiveness advantage.  The results of cost-effectiveness analysis were supported by sensitivity analysis.