OBJECTIVE： To investigate the effects of puerarin on bone mineral density around the femoral prosthesis of elderly women after osteoporotic fracture artificial hip joint replacement. METHODS： 99 elderly women after osteoporotic fracture artificial hip joint replacement were divided into control group （49 cases） and test group （50 cases） according to random number table. Control group received conventional treatment： calcium carbonate and vitamin D3+alendronate sodium+salmon calcitonin； test group was additionally given Puerarin injection 200-400 mg dissolved in Glucose injection 500 ml intravenously， qd， on the basis of control group. A treatment course lasted for 20 d， and both groups received 2 courses of treatment. The hip joint function score and bone mineral density around the femoral prosthesis of 2 groups were observed and compared after surgery， and the occurrence of ADR was also observed. RESULTS： 3 and 2 patients withdrew from control group and test group， respectively. 18 months after surgery， the patients with hip joint function score ranged 70-79 in test group was significantly less than in control group； the rate of excellent hip joint function score in test group was significantly higher than in control group， with statistical significance （P＜0.05）. 15 and 18 months after surgery， bone mineral density in R1-R5 range of Gruen range in test group was slightly higher than in control group， without statistical significance （P＞0.05）； bone mineral density in R6-R7 range was significantly higher than control group （89.58％  vs. 69.57％）， with statistical significance （P＜0.05）. The prosthesis loosening was not found in both groups， and ADR was also not found as fever， erythra， nausea， vomiting， headache， dizziness， etc. CONCLUSIONS： For the use of puerarin in elderly women after osteoporotic fracture artificial hip joint replacement， puerarin can increase the periprosthetic femur bone mineral density with good safety.