OBJECTIVE： To explore the regularity and characteristics of anaphylactoid reactions induced by Magnesium isoglycyrrhizinate injection， and provide reference for clinical rational drug use. METHODS： 27 ADR reports induced by Magnesium isoglycyrrhizinate injection from Hunan Center for ADR Monitoring from Jan. 2014 to Mar. 2015 were retrospectively analyzed. RESULTS： In the 27 cases， 15 were male （55.56％） and 12 were female （44.44％）， with percentage of 1.25 ∶ 1； ADR mainly occurred in patients with 41-60 years old （51.85％）； involved organ/system were mainly skin and its appendages （35.85％） and systemic damage （26.42％）， the main clinical manifestations were rash， itching， fever， chills， vomiting and dizziness； there were 7 severe ADR reports （25.92％）， mainly showed chills， fever and other systemic symptoms； most ADR can be cured （40.74％） or relieved （55.56％） by related processing. CONCLUSIONS： There are no risk tips for severe allergic reactions in instruction， it is necessary to strengthen post-marketing surveillance and further improve the drug instructions to reduce the risk of severe ADR induced by Magnesium isoglycyrrhizinate injection.