OBJECTIVE： To investigate the characteristics and general regularity of adverse drug reaction（ADR）induced by meglumine adenosine cyclophosphate， and to provide reference for rational drug use in the clinic. METHODS： Using “meglumine adenosine cyclophosphate” and “ADR” as keywords， literature were retrieved and analyzed statistically from CJFD，Wanfang database and VIP database according to inclusion and exclusion criteria until Feb.2016. RESULTS： A total of 17 literatures were included， involving 20 patients， with the ratio of male to female was 1 ∶ 1. Most patients aged more than 60 years， accounting for 55.00％ （11 cases）； ADRs often occurred within 30 min during medication （18 cases， 90.00％）； 14 cases （70.00％） were caused by drug combination； ADRs involved multiple organs/systems， the most common damages were systemic injury （12 cases， 27.91％）， skin and its appendants （11 cases， 25.58％）， and the most serious were anaphylactic shock （7 cases）. CONCLUSIONS： Clinical staffs should pay attention to ADRs induced by meglumine adenosine cyclophosphate， drug use strictly in accordance with package inserts and its ingredients of excipients， and closely monitor and prevent the occurrence of ADRs.