OBJECTIVE： To observe the clinical efficacy and safety of Bromfenac sodium eyed drops in the treatment of xerophthalmia. METHODS： 80 patients with xerophthalmia were randomly divided into observation group and control group， with 40 cases in each group. Control group was given 0.1％ Sodium hyaluronate， one drop， qd； observation group was given 0.1％ Sodium hyaluronate eye drops， one drop， bid. Both groups received 14 d of treatment. The subjective symptom and sign， the time of lacrimal film break-up， fluorescent staining score and schemer test were observed in 2 groups before treatment， 3， 7， 14 d after treatment. Clinical efficacy and the occurrence of ADR were observed in 2 groups. RESULTS： There was no statistical significance in subjective symptom and sign， the time of lacrimal film break-up， fluorescent staining score and tear between 2 groups before treatment， 3， 7 d after treatment （P＞0.05）. 14 d after treatment， subjective symptom and sign and fluorescent staining score of 2 groups were decreased significantly， and the time of lacrimal film break-up was prolonged and secretion was increased significantly； the observation group was significantly better than the control group， with statistical significance （P＜0.05）. The cure rate of observation group was 60.0％， which was significantly higher than that of control group （35.0％）， with statistical significance （P＜0.05）. There were no statistical significance in ADR between 2 groups （P＞0.05）. CONCLUSIONS： Sodium hyaluronate eye drops is effective for xerophthalmia， and can relieve the symptoms with good safety.