OBJECTIVE： To observe clinical efficacy and safety of Cayratia japonica cream in the treatment of wound after high complex anal fistula surgery. METHODS： 72 patients with high complex anal fistula were selected and divided into control group and observation group according to random number table， with 36 cases in each group. Both groups received high complex anal fistula surgery. Control group was given vaseline gauze for wound dressing， once a day， after cleaning surgery wound； observation group applied C. japonica cream and then was given vaseline gauze for wound dressing， once a day， after cleaning surgery wound. Both groups was given medicine utile wound healing. Clinical efficacy， healing time， pH value of wound secretion， the rate of pterygium， the amount of wound secretion （by total anout of saked gauze）， pain degree （by VAS score) the incidence of wound secondary infection and the occurrence of ADR were observed in 2 groups after treatment. RESULTS： The cure rate pH value of wound secretion（by total anout of saked gauze）， VAS score and in observation group after treatment were significantly lower or shorter than in control group， with statistical signignificance （P＜0.05）. There were no obvious adverse reactions in 2 groups. CONCLUSIONS： C. japonica cream can effectively reduce recurrence rate after high complex anal fistula surgery and improve wound microenvironment with good safety.