OBJECTIVE： To investigate the effects of Qingyan lifei powder（QYLFP）on relieving cough， reducing phlegm， inhibiting inflammatory and relieving pain. METHODS： The mice were divided into model group， positive control group （Yanjianning tablet， 0.29 g/kg）， QYLFP low-dose， medium-dose and high-dose groups （13.7， 27.3， 54.6 g/kg）， with 10 mice in each group. Model group was given constant volume of normal saline intragastrically， and treatment groups were given relevant medicine intragastrically， once a day， for 7 days. After medication， the effects of relieving cough， reducing phlegm， anti-inflammatory and analgesic of QYLFP were investigated through ammonia-induced cough method， phenol red method， xylene-caused mice ear edema test and acetic acid writhing test. RESULTS： Compared with model group， the cough times of those groups decreased significantly， except for QYLFP low-dose group； the cough incubation period in QYLFP high-dose group prolonged significantly （P＜0.05 or P＜0.01）. The phenol red excretion amount and writhing times within 20 min of mice decreased significantly and ear edema relieved significantly in positive control and QYLFP high-dose group （P＜0.05 or P＜0.01）. CONCLUSIONS： QYLFP has good effects on relieving acough， reducing sputum and inhibiting inflammatory and relieving pain.