OBJECTIVE： To investigate the role of clinical pharmacists intervening in use of antibacterials. METHODS： 90 patients who received antibacterials in our hospital during Jan.-Dec. 2014 were included in control group， and 90 patients who received antibacterials in our hospital during Jan.-Dec. 2015 were included in intervention group. Control group received conventional antibacterials education. In observation group， clinical pharmaceutical intervention was implemented actively， such as hierarchical management of antibacterials and implementation feedback， training and exam， ward round. Irrational use of antibacterials was compared between 2 groups as well as administration time， the number of types， the ratio of antibacterial cost in treatment cost and rational rate， etc. RESULTS： The irrational use of drugs， administration time， the number of types and the ratio of antibacterial cost in treatment cost decreased significantly in intervention group and the rate of rational antibacterinal use increased significantly， with statistical significance （P＜0.05）. Based on 2 cases analysis， the recovery of patients in observation group were improved significantly after clinical pharmacists intervention. CONCLUSIONS： Clinical pharmacy has important effect on the use of antibacterials. Through the active cooperation of doctors and clinical pharmacists， it can reduce the irrational use of antibacterials and treatment cost.