OBJECTIVE: To explore the anesthetic effects of remifentanil of different doses combined with propofol for tracheal intubation in children. METHODS: 120 children scheduled for tracheal intubation were randomly divided into group A (40 cases), group B (40 cases) and group C (40 cases). All children forbid food and water 6 h before surgery, intramuscularly injected 0.02 mg/kg atropine 0.5 h before surgery, intravenous access opening, ECG monitoring, then slowly injected propofol 2 mg/kg+ remifentanil 2 μg/kg+vecuronium 0.1 mg/kg+dexamethasone 2 mg within 1 min; group A continuously infused remifentanil 0.1 μg/(kg·min)+propofol 5mg/(kg·h) by microvascular pump; group B continuously infused remifentanil 0.2 μg/(kg·min)+propofol 5mg/(kg·h) by microvascular pump; group C continuously infused remifentanil 0.3 μg/(kg·min)+propofol 5mg/(kg·h) by microvascular pump. Heart rate and mean arterial pressure at different time points, use amount of remifentanil and propofol, postoperative recovery time to spontaneous breathing, extubation time, and the incidence of adverse reactions in all groups were observed. RESULTS: There were no significant differences in the heart rate and mean arterial pressure at different time points in each group (P>0.05). Use amount of propofol, postoperative recovery time to spontaneous breathing, extubation time and the incidence of adverse reactions in group C were significantly lower than group B, which were lower than group A, the use amount of remifentanil in group C was higher than group B, which was higher than group A, with statistical significances (P<0.05). CONCLUSIONS: Remifentanil of different doses combined with propofol has small effects on heart rate and arterial pressure for children in tracheal intubation, while 0.3 μg/(kg·min) remifentanil combined with propofol shows good postoperative recovery and safety.
关键词
不同剂量瑞芬太尼丙泊酚儿童气管插管术麻醉效果安全性
Keywords
Different dosesRemifentanilPropofolChildrenTracheal intubationAnesthetic effectSafety