OBJECTIVE： To compare the efficacy and safety of 4 kinds of statins in the treatment of peripheral atherosclerosis （AS）. METHODS： 168 AS patients were randomly divided into group A （42 cases）， group B （42 cases）， group C （42 cases） and group D （42 cases）. All patients were given low-fat diet + Metoprolol tartrate tablet 50 mg， orally+Nifedipine tablet 5 mg， orally+Aspirin enteric - coated tablet 100 mg， orally， taking in the evening before going to bed. Based on it， group A received Atorvastatin calcium tablet 20 mg， orally， taking in the evening before going to bed； group B received Atorvastatin tablet 20 mg， orally， taking in the evening before going to bed； group C received Pravastatin sodium tablet 20 mg， orally， taking in the evening before going to bed； group D received Rosuvastatin calcium tablet 10 mg， orally， taking in the evening before going to bed. All patients were treated for 6 mongths. TC， TG， LDL-C，HDL-C，MCP-1， TGF-β， MMP-9， IMT， plaque area， plaque number before and after treatment， and the incidence of adverse reactions in each group were compared. RESULTS： After treatment， TC， TG， LDL-C， MCP-1， TGF-β and MMP-9 in each group were significantly lower than before， HDL-C was significantly higher than before； after 3 months， the TC， TG and LDL-C in group B were lower than group A， which was lower than group C and group D， HDL-C in group B was higher than group A， which was higher than group C and group D， MCP-1， TGF-β and MMP-9 in group A and group D were lower than group B and group C； after 6 months， the TC， TG and LDL-C in group B and group C were lower than group A and group D， MCP-1 in group A and group D was lower than group B and group C， MMP-9 and TGF-β in group A and group D were lower than group C， which was lower than group B（P＜0.05）. After 6 months， IMT， plaque number and area in each group were significantly lower than before， IMT in group A and group D was lower than group B and group C， plaque number in group A was lower than group D， which was lower than group B and group C（P＜0.05）， so as the incidence of adverse reactions （P＞0.05）. CONCLUSIONS： Based on conventional treatment， 4 drugs of statins can effectively reduce the level of blood lipid，but rosuvastatin is better than atorvastatin in anti-inflammation and keep plaques stable， the 4 statins have good safety.