OBJECTIVE： To optimize the inclusion and granulating technology of Hegan lipi granules. METHODS： Using yield of inclusion complex and inclusion rate as comprehensive index， the ratio of β-CD to volatile oil， inclusion temperature， inclusion time as factors， orthogonal test was adopted to optimize the inclusion technology of volatile oil from Hegan lipi granules. Using the comprehensive score of moldability， dissolubility， mobility and hygroscopicity as index， the ratio of drug to excipients， volume fraction and amount of ethanol as factors， orthogonal test was adopted to optimize the granulating technology of Hegan lipi granule powdered extract. The quality of prepared granule was evaluated. RESULTS： The optimal inclusion technology of volatile oil was that the ratio of volatile oil to β-CD was 1 ∶ 6 and the inclusion time was 1 h with inclusion temperature of 50 ℃ by saturated aqueous solution method. The optimal granulating technology was that the ratio of drug to excipients was 1 ∶ 1 （extract powder-soluble starch-dextrin ratio was 5 ∶ 3 ∶ 2）， 90％ ethanol were used as the wetting agent with a weight of 20％ extract powder. The verification tests showed that comprehensive scores of 3 batches of granules were 96.8， 95.7， 95.9 （RSD＝0.65％， n＝3）. The quality of them were all in line with the requirement. CONCLUSIONS： Optimized inclusion and granulating technology of Hegan lipi granules are stable and reliable， and can be used for the industrialized production.