OBJECTIVE： To compare the  clinical efficacy and safety of 2 administration routes of glucocorticoid in the treatment of infant acute asthma attack. METHODS： 98 children with acute asthma attack selected from our hospital and divided into inhalation group and oral group according to route of administration， with 49 cases in each group. Inhalation group was given Budesonide inhalation suspension 1 ml added into 0.9％ Sodium chloride injection 2 ml， 10 min by oxygen drive atomization inhalation， bid； oral group was given Prednisone acetate tablet 1-2 mg（≤40 mg/d），tid. Both groups received treatment for 1 week. clinical efficacy， clinical control rate， the time of clinical symptom disappearance， the levels of imflammatory factor and cellular immune were all observed in 2 groups， and the occurrence of ADR was also observed. RESULTS： Clinical total effective rate of inhalation group （93.8％） was higher than that of oral group （87.76％）， without statistical significance （P＞0.05）. Clinical control rate of inhalation group （61.22％） was significantly higher than that of oral group （48.98％）， while the time of clinical symptom disappearance in inhalation group was significantly shorter than in oral group； the levels of eosinophile granulocyte， serum IgE， IL-4 were significantly lower than oral group， with statistical significance （P＜0.05）； CD4+， CD8+， CD4+/CD8+ of inhalation group was slighter higher than those of oral group， without statistical significance （P＞0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Inhalation administration of glucocorticoid is similar to oral administration in the treatment of infant acute asthma attack， but it is better than oral administration in clinical control and can improve clinical symptom and immunologic function fast with good safety.