OBJECTIVE： To provide reference for rational drug use and strengthen the management of adjuvant medication management in the hospital. METHODS： 1 080 and 860 discharged medical records of 12 Vitamins for injection were selected from our hospital during Jun.-Nov. 2014 （pre-special comment group， i.e. group A） and Jun.-Nov. 2015 （post-special comment group， i.e. group B）， respectively. The application of 12 Vitamins for injection， hospitalization stay， drug cost and the incidence of ADR were compared before and after adjuvant medication special comment. RESULTS： After adjuvant medication special comments， the proportion of drug use of no indication， unsuitable solvent selection， irrational drug dosage， drug use of drug interaction and contraindication， drug cost and the incidence of ADR in group B were all lower than in group A， with statistical significance （P＜0.05）. There was no statistical significance in hospitalization stay between 2 groups （P＞0.05）. CONCLUSIONS： Clinical pharmacists adopt adjuvant medication special comments to effectively standardize clinical application of 12 Vitamins for injection in our hospital.