OBJECTIVE： To establish a method for the detection of 24 chemical substances that illegally added into antihypertensive traditional Chinese medicines. METHODS： HPLC-Q-TOF-MS/MS was adopted. The chromatographic conditions were as follows， the column was Agilent Poroshell 120 EC-C18 with mobile phase of 0.05％ formic acid-methanol （gradient elution） at a flow rate of 0.3 ml/min， column temperature was 30 ℃， injection volume was 5 μl. MS conditions were as follows， ion sou- rce was an electrospray ionization source， capillary voltage was 4.0 kV， capillary exit voltage was 135 V， cone voltage was 65 V， desolvation temperature was 350 ℃， drying gas flow rate was 10 L/min， nebulizer pressure was 40 psi， collision energy was 8-45 V； scanning range was m/z 100-1 700； and detection method was positive ion mode （ESI+）. RESULTS： The linear range was 2.0-32 μg/L for captopril nifedipine， hydrochlorothiazide， clonidine hydrochloride， reserpine， 3.0-48 μg/L for amlodipine besylate， felodipine，valsartan，lacidipine， candesartan cilexetil and 2.5-40 μg/L for the other 14 chemical substances （r≥0.995 9）； limit of quantification was not higher than 2.944 1 ng，the limit of detection was not higher than 0.988 5 ng； RSDs of precision， stability and reproducibility tests were no higher than 5.1％； recoveries were 81.5％-115.5％（RSD were 1.81％-4.86％，n＝9）. CONCLUSIONS： The method is specific， sensitive， simple and rapid， and suitable for the detection of chemical substances that illegally added into antihypertensive traditional Chinese medicines.