OBJECTIVE： To establish the quality standards for Fufang ningshen granule. METHODS： TLC was used for the qualitative identification of Radix angelicae and White paenoy； HPLC was adopted for the contents determination of spinosin and verbascoside： the column was Kromasil C18 with the mobile phase of acetonitrile-0.1％ acetic acid （16 ∶ 84，V/V） at a flow rate of 1.0 ml/min， detection wavelength was 330 nm， column temerpature was 30 ℃. RESULTS： The TLC spots of R. angelicae and W. paenoy were clear with good separation， negative control without interference. The linear range was 0.055 44-0.277 2 μg for spinosin （r＝0.999 4） and 0.055 98-0.279 9 μg for verbascoside （r＝0.999 5）； RSDs of precision， stability and reproducibility tests were lower than 3.0％； recoveries were 95.62％-100.53％ （RSD＝1.77％，n＝9） and 95.63％-102.57％ （RSD＝2.74％，n＝9）. CONCLUSIONS： The standard can be used for the quality control of Fufang ningshen granule.