OBJECTIVE： To establish a method for the determination of dissolution of Xiaocaihu pill，and compare the difference of preparation from different manufacturers. METHODS： Using 0.1 mol/L HCl as dissolution medium， rotating basket method was used to determine the dissolution of preparations. HPLC was adopted to determine the content of baicalin： column was TSKgel ODS C18 with mobile phase of methanol-water-phosphoric acid （65 ∶ 35 ∶ 0.7，V/V/V） at a flow rate of 1 ml/min， detection wavelength was 280 nm， column temperature was 30 ℃， and injection volume was 5 μl. RESULTS： The linear range of baicalin was 0.488-124.8 mg/L （r＝0.999 9）； RSDs of precision， stability and reproducibility tests were lower than 2.0％； recovery was  100.14％-104.78％（RSD＝1.58％，n＝9）. The average t50（50％ dissolution time） of baicalin was 85.81 min. CONCLUSIONS： The method is simple with good precision， stability and reproducibility， and can be used for the dissolution determination of Xiaocaihu pill. Xiaocaihu pill from different manufacturers shows great differences， both preparation formulation and clinical use should attach importance to the dissolution of solid preparations.