OBJECTIVE： To explore function transformation mode of pharmacy personnel based on adult education theory and policy guidance， and to provide reference for improving pharmacy personnel adapting to “New Medical Reform” and function transformation. METHODS： Through analyzing working model and current situation of pharmacy personnel， educational background structure of pharmacy personnel and clinical pharmacy developed by pharmacy personnel， combined with Knowles’s theory of adult education， Mezirow’s theory of transform learning， situated learning and other adult learning theories， function transformation of pharmacy personnel were improved and served the patients using pharmacoeconomic method. RESULTS & CONCLUSIONS： Under the background of deepening medical reform， especially the cancel of drug addition， the operation mechanism and model of pharmacy will greatly change； national policy incentive mechanism also promote the change from traditional function which focus on dispensing and drug supply to “patient-oriented” pharmaceutical management model and role positioning. Pharmacy personnel should improve function transformation and role positioning by using the theory of adult learning and pharmacoeconomics method， combined with the policy and mechanisms； taking patients as the centre， it becomes an important pharmacy personnel working content and target so that reasonable， effective and economical drugs can be provided for the patients.