OBJECTIVE： To explore the role of clinical pharmacists providing pharmaceutical care for hemodialysis patients complicated with subacute infective endocarditis（IE）. METHODS： Clinical pharmacists participated in the anti-infection treatment for a hemodialysis patients complicated with subacute IE， according to the antimicrobial spectrum， laboratory and imaging findings， and patient’s condition changes， assisted physician to optimize the regimen， clinical pharmacists suggested to give imipenem cilastatin sodium after hemodialysis， adjust the initial dose of teicoplanin and give 1 g vancomycin firstly， and maintained 0.5 g after hemodialysis， then adjust its dose based on blood plasma concentration； during treatment， clinical pharmacists closely observed the treatment effect and adverse reactions， providing blood plasma concentration monitoring， medication reminding and medication education. RESULTS： Physicians adopted parts of suggestions of clinical pharmacists， no fever was found， hemogram returned to normal， no abnormal echocardiography， and patient discharged. CONCLUSIONS： Clinical pharmacists guarantee the safety and efficacy of drug use by adopting dose of anti-infection drugs， evaluating efficacy， monitoring adverse reactions and vancomycin plasma concentration， and assisting physicians to optimize treatment regimen.