OBJECTIVE： To observe clinical efficacy of Huhuang burn liniment in the treatment of burn. METHODS： 400 patient with burn selected from outpatient department were divided into control group and treatment group according to random number table， with 200 cases in each group. Control group was given Sulfadiazine silver cream with thickness of 0.15-0.30 mm thick， once a day after cleaning the wound. Treatment group was given Huhuang burn liniment， 1-3 times daily until completely healing. Clinical efficacy， healing time of the wound and bacterial infection rate were compared between 2 groups， VAS score was used to evaluate pain degree and the occurrence of ADR was observed. RESULTS： Clinical efficacy， healing time of the wound and infection rate of treatment group were better than those of control group， with statistical significance （P＜0.05）. There was no statistical significance in VAS score between 2 groups before treatment （P＞0.05）. After treatment， VAS score of 2 groups were decreased significantly， and the treatment group was significantly lower than the control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Huhuang burn liniment is effective in the treatment of burn， and can promote wound healing， avoid the infection of the wound and effectively relieve pain with good safety.