OBJECTIVE： To investigate the effects of Jintiange capsules combined with zoledronic acid on bone mineral density （BMD）， VAS scores and lab indexes of patients with postmenopausal diabetic osteoporosis. METHODS： 140 patients with postmenopausal diabetic osteoporosis were divided into control group and treatment group according to randomized blocks， with 70 cases in each group. Both group received 0.9％ Sodium chloride injection 100 ml intravenously before and after treatment， and were given vitamin D and calcium. Control group was given Zoledronic acid injection 5 mg intravenously for more than 15 min， once every 4 weeks. Treatment group was additionally given Jintiange capsules 1.2 g， po， tid， on the basis of control group. Both groups received 6 months of treatment. BMD， VAS score， lab indexes before and after treatment and the occurrence of ADR were compared between 2 groups. RESULTS： After treatment， BMD of 2 groups were increased significantly compared to before treatment， and the treatment group was significantly higher than the control group， with statistical significance （P＜0.05）. VAS score of 2 groups after treatment were significantly lower than before treatment， and VAS score of treatment group was significantly lower than that of control group after treatment， with statistical significance （P＜0.05）. The levels of blood calcium and serium inorganic phosphorus had no change in 2 groups； but the level of osteocalcin was significantly higher than before treatment， while the level of bone-specific alkaline phosphatase was significantly lower than before treatment， and the levels of osteocalcin and bone-specific alkaline phosphatase in treatment groups were significantly better than in control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups（P＞0.05）. CONCLUSIONS： Jintiange capsules combined with Zoledronic acid injection in the treatment of postmenopausal osteoporosis patients with diabetes can significantly increase BMD， relieve pain and improve lab index levels. Moreover， it doesn’t increase the risk of ADR.