OBJECTIVE： To establish a method for simultaneous determination of danshensu， salvianolic acid B， protocatechuic aldehyde， paeoniflorin and ferulic acid in Jingzhi guanxin granule. METHODS： HPLC was performed on the column of Zorbax Eclipse XDB-C18 with mobile phase of acetonitrile-methanol -0.5％ H3PO4（gradient elution） at a flow rate of 1.0 ml/min， the detection wavelength was 280 nm （for danshensu， protocatechuic aldehyde， salvianolic acid B），230 nm （for ferulic acid） and 320 nm （for paeoniflorin）， column temperature was 30 ℃，injection volume was 10 μl. RESULTS： The linear range was 1.19-478.34 μg/ml for danshensu（r＝0.999 9）， 0.11-44.93 μg/ml for protocatechuic aldehyde（r＝0.999 9），7.49-995.20 μg/ml for salvianolic acid B（r＝0.999 7）， 0.95-379.39 μg/ml for paeoniflorin （r＝0.999 9） and 0.01-3.12 μg/ml for ferulic acid （r＝0.999 5）； the limits of quantitation were 1.91 ng， 0.36 ng， 150.00 ng， 2.74 ng and 0.10 ng， limit of detection were 0.96 ng， 0.10 ng，45.00 ng，1.52 ng and 0.03 ng； RSDs of precision， stability and reproducibility tests were lower than 2％； recoveries were 98.06％-99.47％ （RSD＝0.52％，n＝6）， 98.01％-99.49％ （RSD＝0.70％，n＝6）， 98.44％-99.45％ （RSD＝0.37％，n＝6）， 96.94％-100.71％ （RSD＝1.27％，n＝6） and 95.44％-100.44％ （RSD＝1.90％，n＝6）. CONCLUSIONS： The method is simple and accurate， and suitable for the simultaneous determination of danshensu， salvianolic acid B， protocatechuic aldehyde， paeoniflorin and ferulic acid in Jingzhi guanxin granule.