OBJECTIVE： To optimize the extraction technology of Compound Lamiophlomis rotata gel plasters. METHODS： With the yield of extractum， the extract rate and purity （sum of contents of 5 marker components/extract rate） of 5 marker components （loganin acid， shanzhiside methyl ester， gentiopicroside， 8-O-acetyl shanzhiside methyl ester， 2′ ，4′ -dihydroxychalcone） as indexes， with ethanol amount， ethanol concentration and extraction time as factors， uniform design （UD） was used to optimize technology parameters. Then dynamic optimization extraction method （DOEM） was employed to further optimize extraction time. RESULTS： The optimum extraction conditions of UD were as follows as 8-fold 90％ ethanol， extracting 2 times， 1 h each time. The yield of extractum was 24.37％， and the extract rate of 5 marker components were 0.10％， 0.51％， 1.65％， 0.74％ and 0.19％， respectively； the purity of them was 13.11％. The extraction time was reduced to 40 times at first time and 30 times at second time by DOEM； the extract rates of 5 marker components were 0.10％， 0.52％， 1.78％， 0.75％ and 0.31％， respectively； the purity of them was 14.08％. CONCLUSIONS： The optimum extraction conditions of UD are reasonable and stable. DOEM can significantly reduce extraction time， consumption and production costs.