OBJECTIVE： To establish a method for the dissolution determination of Dronedarone hydrochloride tablet， and evaluate the quality consistency of its generic and original preparations. METHODS： UV spectrometry was performed on the column of 288 nm， dissolution media of Phosphate buffer solution （pH4.5），0.1 mol/L Hydrochloric acid solution [adding into 0.5％ sodium dodecyl sulfate （SDS）]， Phosphate buffer solution [pH6.8， adding into 0.5％SDS] and water， volume of dissolution medium was 1 000 ml， rotation speed was 75 r/min， the dissolution of generic and original preparations of Dronedarone hydrochloride tablet was detected， and the similarity of dissolution curve was evaluated by calculating the similarity factor （f2）. RESULTS： The linear range of dronedarone hydrochloride was 2.147-25.764 μg/ml； RSDs of precision， stability and reproducibility tests were lower than 2.0％； recoveries 4 dissolution media were 99.53％-101.05％（RSD＝0.48％，n＝9）， 98.95％-100.05％ （RSD＝0.39％，n＝9）， 99.54％-100.20％ （RSD＝0.24％，n＝9） and 98.54％-100.06％（RSD＝0.44％，n＝9）. In the 4 dissolution media， f2 of the dissolution curve of 3 batches of generic and original preparations of Dronedarone hydrochloride tablet was 56， 60， 63， 68， 68， 52， 59， 67， 65， 68， 76， 62， respectively. CONCLUSIONS： The method is suitable for the dissolution determination of Dronedarone hydrochloride tablet； meanwhile， the in vitro dissolution curves of generic and original preparations of Dronedarone hydrochloride tablet show similarity， so the quality consistency is good.