To observe the efficacy and safety of Guizhi fuling capsule combined with leuprolide acetate in the treatment of endometriosis （EMS） after laparoscopicsurgery. METHODS： 87 EMS patients were randomly divided into control group （44 cases） and observation group （43 cases）. Control group received EMS resection under laparoscope， 3.75 mg Leuprolide acetate for injection was given in the first day of postoperative first menstruation by intramuscular injection， once a day. Observation group additionally received 0.93 g Guizhi fuling capsule， 3 times a day. The treatment course for both groups was 6 months. Clinical efficacy， estradiol （E2）， follicle stimulating hormone （FSH）， luteinizing hormone （LH） and prolactin （PRL） levels before and after treatment， recurrence after 6 months and the incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， recurrence rate was significantly lower than control group， the differences were statistically significant （P＜0.05）. Before treatment， there were no significant differences in E2， FSH， LH and PRL in 2 groups （P＞0.05）； after treatment， E2， FSH， LH and PRL in 2 groups were significantly lower than before， and E2， FSH and LH in observation group were lower than control group， the differences were statistically significant （P＜0.05）， but there was no significant difference in PRL in 2 groups （P＞0.05）. And there was no significant difference in the incidence of adverse reactions in 2 groups （P＞0.05）. CONCLUSIONS： After laparoscope resection， Guizhi fuling capsule combined with leuprolide acetate can effectively improve efficacy， reduce sex hormone level and recurrence rate， and do not increase the incidence of adverse reactions in the treatment of EMS.