OBJECTIVE： To provide a reference for improvement in the quality of pharmaceutical care rendered by the prescription-checking pharmacists in the outpatient pharmacy. METHODS： The existing problems， opportunity and challenge in the pharmaceutical care of the prescription-checking pharmacists in our hospital were analyzed on the basis of the specific requirements of new health-care reform for pharmacists’ checking prescriptions， and relevant suggestions were put forward as to existing problems. RESULTS & CONCLUSIONS： The prescription-checking pharmacists in our hospital have problems to meet the requirements of new health-care reform for prescription-checking pharmacists due to their limited professional abilities， imperfect informatization software， less trust paid by patients to prescription-checking pharmacists and failure to rectify common off-label use through administrative intervention. It is suggested that the on-the-job training of the prescription-checking pharmacists be strengthened， informatization software be improved， importance be attached to the interaction among doctors， pharmacists and patients and the hospital policy support be strengthened to meet the requirements of new health-care reform， embodying the pharmacists’ professional value and promoting rational drug use.