OBJECTIVE： To investigate the efficacy and safety of somatostatin， pantoprazole combined with thrombin in the treatment of acute upper gastrointestional hemorrhage （AUGH）. METHODS： Clinical data of 136 AUGH was retrospectively analyzed and divided into control group（68 cases） and observation group（68 cases）. Control group received pantoprazole 8 mg/h continuous micro-infusion for 72 h+thrombin 2 000 U adding into 15 ml 0.9％ Sodium chloride injection， 2 times/d. Observation group was additionally given somatostatin 0.25 mg/h continuous micro-infusion maintaining 72 h. 0.25 mg somatostatin was intravenously injected for 3-5 min when the first use of somatostatin. They were treated for 1 week. The clinical efficacy， hemostatic time， hospitalization time， 24 h hemostatic rate， 48 h hemostatic rate and rehemorrage rate in 2 groups were observed， and the incidence of adverse reactions was recorded. RESULTS：Total effective rate， 24 h hemostatic rate， 48 h hemostatic rate in observation group were significantly higher than control group， hemostatic time， hospitalization time were significantly shorter than control group， with statistical significances （P＜0.05）. And there was no significant difference in the incidence of total adverse reactions （P＞0.05）. CONCLUSIONS： Somatostatin， pantoprazole combined with thrombin show good efficacy in the treatment of AUGH， it can shorten hemostatic time and hospitalization time， reduce rehemorrage rate， and do not increase the incidence of adverse reactions.