OBJECTIVE： To investigate the effects of Qingyi jiedu decoction on pancreatitis rats after endoscopic retrograde cholangiopancreatography （ERCP）. METHODS： 60 rats were randomly divided into normal group， model group， positive control group （Octreotide injection 50 μg/kg， sc） and Qingyi jiedu decoction high-dose， medium-dose and low-dose groups [56.5， 33.9， 11.3 g（crude drug）/kg，ig] with 10 rats in each group. Except for normal group， post-ERCP pancreatitis model was induced in those groups. After modeling， treatment groups were given relevant medicine， and normal group and model group were given distilled water intragastrically. The serum levels of IL-10， TNF-α， motilin and amylase were determined. The pathological changes of pancreatic tissues were observed and scored. RESULTS： Compared with normal group， the serum levels of amylase and TNF-α in model group and treatment groups were increased significantly， while the levels of motilin and IL-10 were significantly decreased （P＜0.05）； obvious inflammation was found in pancreatic tissues， and pathological score increased significantly （P＜0.05）. Compared with model group， above indexes of treatment groups were improved significantly， and Qingyi jiedu decoction groups were better than positive control group， with statistical significance （P＜0.05）. CONCLUSIONS： Qingyi jiedu decoction can improve pancreatitis after ERCP of rats， reduce the serum levels of amylase and TNF-α， and increase the serum levels of motilin and IL-10.