OBJECTIVE： To investigate the effects of different doses of sufentanil citrate on hemodynamic indexes and stress response indexes of Crouzon syndrome children with craniofacial reconstruction. METHODS： 60 cases of Crouzon syndrome undergoing craniofacial reconstruction were selected from our hospital during Jan. 2010-Jan. 2016， and then randomly divided into group A， group B and group C， with 20 cases in each group. 3 groups were given pump injection of Propofol injection 4-8 mg/（kg·h）for anesthesia induction+Sufentanil citrate injection  [group A 0.3 μg/（kg·h），pump injection； group B 0.6 μg/（kg·h），pump injection； group C 1.0 μg/kg，iv，0.5 h/time] for anesthesia maintenance，  Cisatracurium besilate for injection  0.1 mg/kg，iv， every 40 min， drug withdrawal 5 min before the end of surgery. The hemodynamic indexes （MAP， HR） and stress response indexes （ACTH， cortisol） were observed in 3 groups at different time points as well as the occurrence of ADR. RESULTS： MAP levels of group C at 5 min after skin incision， 1 h after operation and immediately at the end of surgery were significantly higher than before anesthesia， while those of group B were significantly higher than group C at same time points. HR of group A at 1 h after surgery and that of group B at 5 min after skin incision and 1 h after surgery were significantly higher than before anesthesias； HR of group  B at 1 h after surgery was significantly lower than that of group A， and its HR at 5 min after skin incision and 1 h after surgery were significantly lower than those of group C. ACTH levels of 3 groups at 5 min after skin incision， 1 h after surgery and immediately after the end of surgery were significantly higher than before anesthesia. ACTH levels of group B at 5 min after skin incision， 1 h after surgery and immediately after the end of surgery were significantly lower than those of group A and C， and the group A was significantly lower than the group C at same time points. Cortisol levels of group A at 1 h after surgery， and those of group C at 5 min after skin incision， 1 h after surgery and immediately after the end of surgery were significantly higher than before anesthesia. Cortisol levels of group B at 1 h after surgery were significantly lower than those of group A；  cortisol levels of group A at 5 min after skin incision and immediately after the end of surgery and those of group B at 5 min after skin incision， 1 h after surgery and immediately after the end of surgery were all significantly lower than those of group C. There were statistical significance all above （P＜0.05）. No obvious ADR was found in 3 groups. CONCLUSIONS： Pump injection of sufentanil citrate 0.6 μg/（kg·h） can maintain analgesic effect of  Crouzon syndrome children with craniofacial reconstruction， can keep  hemodynamics stable and effectively inhibit stress response during surgery with good safety.