OBJECTIVE： To study the possible influential factors of chronic hepatitis B （CHB） recurrent after adefovir ester withdrawal. METHODS： CHB patients receiving adefovir acetate met drug with drawal standard in our hospital during Jan. 2013-Jan. 2015 were selected as the research object. 120 patients suffering from CHB recurrent after drug withdrawal were included in observation group， and 100 patients without CHB recurrent were included in control group. The age， sex， smoking history， drinking history and family history of hepatitis B， biochemical indicators， hepatitis B serology indexes， virology indexes were compared between 2 groups as well as the occurrence of ADR. RESULTS： There was no statistical significance in family history of hepatitis B and smoking history between 2 groups （P＞0.05）； the proportion of male in observation group was significantly higher than in control group， patients aged 46 years above of observation group was significantly more than those of control group， patients with drinking history was significantly more than control group， with statistical significance （P＜0.05）. HBV-DNA load of observation group were significantly lower than those of control group， with statistical significance （P＜0.05）. There was no statistical significance in lab indicators and HBeAg positive rate between 2 groups （P＞0.05）. No ADR was found in 2 groups during treatment， such as the elevation of serium inorganic phosphorus， creatine kinase， usea nitrogen and creatinine disorder. CONCLUSIONS： HBV-DNA load， advanced age， female and drinking history may be influential factors of CHB recurrence after drug withdrawal during initial treatment.