OBJECTIVE： To evaluate the similarity of in vitro dissolution of self-made and original preparation of Ramelteon tablet. METHODS： The paddle method was adopted with rotational speed of 50 r/min， using water， pH1.2 hydrochloric acid solution， pH4.0 acetate buffer solution and pH6.8 phosphate buffer solution as dissolution media， HPLC was used to determine the cumulative dissolution of main components of self-made and original preparation of Ramelteon tablet at different time points， dissolution profile was drew， then f2 was used to evaluate its similarity. RESULTS： In the 4 dissolution media， the f2 of self-made and original preparation of Ramelteon tablet was 62.8， 80.0， 77.7， 76.2， respectively， which indicated that the dissolution profiles showed similarity. CONCLUSIONS： The established HPLC is suitable for the dissolution determination of Ramelteon tablet； the dissolution profiles of the self-made and original preparations are similar， it preliminary indicates the prescription and technological rationality of self-made preparation.