OBJECTIVE： To provide reference for rational use of auxiliary therapeutic drug for injection in the clinic. METHODS： 2 221 inpatient medical records of top 10 auxiliary therapeutic drugs in the list of monthly amount were randomly selected from our hospital （a tumor hospital） during 2013-2015. Those medical records were commented and irrational ones were analyzed. RESULTS： Among 2 221 medical records， there were 680 irrational medical orders of auxiliary therapeutic drugs， with qualified rate of 69.38％. Top 3 types of irrational drug use were unsuitable usage and dosage （32.94％）， unsuitable drug combination （31.62％）， drug use without indication or disagreeing with indication （27.50％）. Among top 10 auxiliary therapeutic drugs for injection in the list of amount， the qualified rate of 12 compound vitamin for injection was the highest， being 85.00％； Riboflavin sodium phosphate injection was the lowest， being 56.67％. CONCLUSIONS： It’s important to strengthen standardized administration for auxiliary therapeutic drug for injection in our hospital so as to reduce the irrational use of drugs in the treatment of rumor.