OBJECTIVE： To establish a method for the dissolution determination of Tamibarotene tablet. METHODS： HPLC was performed on the column of Diamonsil C18 with mobile phase of methanol-water-acetic acid （85 ∶ 15 ∶ 1，V/V/V） at a flow rate of 1.0 ml/min， detection wavelength was 235 nm，column temperature was 25 ℃， and injection volume was 20 μl. The paddle method was used to determine the dissolution， using pH6.8 phosphate buffer dissolution as medium， medium volume was 900 ml， the rotating speed was 50 r/min， taking samples after 60 min. RESULTS： The linear range of tamibarotene was 0.801-2.804 μg/ml （r＝0.999 6）； RSDs of precision， stability and reproducibility tests were lower than 3％； recovery was 99.58％-100.90％ （RSD＝0.25％，n＝9）； the accumulative dissolution rate of 3 batches of samples was 98.25％，96.54％，92.38％（n＝6）. CONCLUSIONS： The method simple， accurate with high sensitivity and specificity， and suitable for the dissolution determination of Tamibarotene tablet.