OBJECTIVE： To explore the role of clinical pharmacists participating in drug therapy for patients with severe infections. METHODS： Clinical pharmacists participated in drug treatment for a patient with tropical candidemia and assisted physicians to adjust anti-infective treatment plan. According to the results of blood culture， clinical pharmacists suggested Piperacillin sodium and tazobactam sodium for injection 3.75 g， ivgtt， q8 h+Caspofungin acetate for injection 50 mg （initial dose of 70 mg）， ivgtt， qd， for symptomatic treatment； increased the daily dose of Caspofungin acetate for injection to 50 mg， ivgtt， bid due to plasma exchange； Caspofungin acetate for injection 50 mg，ivgtt，qd+ Amphotericin B for injection 0.1 mg/kg，ivgtt，qd for anti-infective plan due to the possible “contradiction” of echinocandins； closely monitored ADR， such as allergy， erythra， renal function injury. RESULTS： Physicians adopted the suggestions of clinical pharmacists， vital sign of patient kept stable， and tropical candidemia was not detected in the blood culture； the patient was transferred to general ward for further treatment. CONCLUSIONS： Based on the results of blood calture， clinical symptoms and the characteristics of drug effects， clinical pharmacists participated in the treatment for the patient with severe infection， retrieved related treatment guideline， assisted physicians to adjust anti-infective plan and closely monitored possible ADR so as to guarantee the effectiveness and safety of anti-infective treatment.