OBJECTIVE： To observe the effects of Cholinesterase inhibitor combined with Compound haishe capsule on prognosis of patients with Alzheimer’s disease （AD）. METHODS： 210 AD patients were divided into donepezil group， rivastigmine group， galantamine group， Compound haishe capsule group， donepezil + Compound haishe capsule group， rivastigmine + Compound haishe capsule， and galantamine + Compound haishe capsule group， 30 cases in each group according to visiting order. Donepezil group received Donepezil hydrochloride tablet 5 mg （＜1 month） before going to bed， 10 mg （≥1 month）， po， qd； rivastigmine group received Rivastigmine hydrogen tartrate capsule 1.5 mg （＜1 month） before going to bed， 3.0 mg （≥1 month）， po， bid； galantamine group received Galantamine hydrobromide tablet 2 mg （＜2 weeks）， 4 mg （2-4 weeks）， 6 mg （＞4 weeks）， po， bid； Compound haishe capsule received Compound haishe capsule 3 casuples， po， tid； donepezil + Compound haishe capsule group received Donepezil hydrochloride tablet 5 mg， po， qd + Compound haishe capsule 3 casuples， po， tid； galantamine + Compound haishe capsule group received Rivastigmine hydrogen tartrate capsule 1.5 mg， po， bid + Compound haishe capsule 3 casuples， po， tid； galantamine + Compound haishe capsule group received Galantamine hydrobromide tablet 4 mg， po， bid + Compound haishe capsule 3 casuples， po， tid. The treatment course for all groups was 3 months. Mini-mental state examination （MMSE）， AD dementia rating scale （ADAS-cog） and ability of daily life （ADL score） before and after treatment， and TESS score after treatment in all groups were observed， and the occurrence of ADR was observed. RESULTS： There was no statistical significance in MMSE， ADAS-cog and ADL score between 2 groups before treatment （P＞0.05）.After treatment， MMSE， ADAS-cog and ADL score in all groups were obviously improved； MMSE scores in ChEI combined with Compound haishe capsule groups were obviously higher than appropriate ChEI alone groups and Compound haishe capsule alone group， ADAS-cog and ADL scores were obviously lower than  appropriate ChEI alone groups and Compound haishe capsule alone group； TESS scores incidence of adverse reactions in Compound haishe capsule alone group or combined with ChEI groups were obviously lower than appropriate ChEI alone groups and Compound haishe capsule group， the differences were statistically significant （P＜0.05）. CONCLUSIONS： ChEI combined with Compound haishe capsule can effectively improve the mental state of AD patients， cognitive function and life activity， with higher safety.