OBJECTIVE： To observe the effects of Vitamin B6 on efficacy and related indexes of patients with peripartum cardiomyopathy （PPCM）. METHODS： 64 PPCM patients were randomly divided into control group （32 cases） and observation group （32 cases）. Control group received diuretic drugs， angiotensin converting enzyme inhibitors or angiotensin Ⅱ receptor antagonist， β-blockers， digitalis， low molecular weight heparin and other conventional treatment. Observation group additionally received Vitamin B6 tablet 50 mg， orally， twice a day. They treated for 2 weeks. Clinical efficacy， serum prolactin （PRL）， brain natriuretic peptide （BNP）， left ventricular end-diastolic diameter （LVEDD） before and after treatment，milk back rate and the incidence of adverse reactions in 2 groups were observed. RESULTS： There was no significant difference in the total effective rate in 2 groups （P＞0.05）. Before treatment， there were no significant differences in PRL， BNP and LVEDD in 2 groups （P＞0.05）. After treatment， PRL， BNP and LVEDD in 2 groups were significantly lower than before， and observation group were lower than control group， with statistical significances （P＜0.05）. And the milk back rate in observation group was significantly higher than control group， with statistical significance （P＜0.05）. There were no obvious severe adverse reactions during treatment. CONCLUSIONS： Based on conventional treatment， Vitamin B6 shows similar efficacy and safety with conventional treatment in the treatment of PPCM， though it is superior to conventional treatment in terms of decreasing PRL level， it has high milk back rate.