OBJECTIVE： Analyze drug use of pediatrics in China， and to provide reference for promoting  research， development and supply of pediatric drugs. METHODS： Analyze the data of drug use in 2 632 514 pediatric patients aged from 0 to 14 of 78 sample hospitals from Beijing， Shanghai， Tianjin， Hangzhou， Zhengzhou， Guangzhou and Chengdu in “The Hospital Prescriptions Cooperation Project” of Hospital Pharmacy Professional Committee of Chinese Pharmaceutical Association， statistical analysis was performed by using Excel and Access software. RESULTS： Pediatric patients in 78 sample hospitals of 7 regions had used 1 572 kinds of drugs from 2013 to 2014， but only 31.04％ of drugs were pediatric drugs； both the ratio of pediatric drug types and the ratio of pediatric drugs use frequency had a great gap in different drug classifications. The ratio of drug use frequency in injection administration was 57.97％， and it was greatly higher than that of oral administration （31.04％）. Among oral solid preparations， the ratio of drug use frequency for drugs with unreasonable specification was 29.57％， and ratio of drug types was 40.99％. CONCLUSIONS： The pediatric patients had a great drug shortage in kinds， dosage forms and specifications in 78 sample hospitals of 7 regions during 2013-2014. Off-label drug use， high frequence of injection use， tablets used after breaking and other irrational phenomena were found in pediatric patients during clinical drug therapy， which reduced high risk of drug use. It is recommended that government should strengthen and improve incentives mechanism of research， development and supply of pediatric drugs， so as to solve pediatric drug shortage in China， promote rational clinical drug therapy for children and guarantee the safety of drug use in pediatrics.